PittsburghV1, France, Analysis, bibRecord, 000310

Vitamin D and the risk of dementia and Alzheimer disease

Identifieur interne : 000310 ( France/Analysis ); précédent : 000309; suivant : 000311

Vitamin D and the risk of dementia and Alzheimer disease

Auteurs : Thomas J. Littlejohns [Royaume-Uni] ; William E. Henley [Royaume-Uni] ; Iain A. Lang [Royaume-Uni] ; Cedric Annweiler [France] ; Olivier Beauchet [France] ; Paulo H. M. Chaves [États-Unis] ; Linda Fried [États-Unis] ; Bryan R. Kestenbaum [États-Unis] ; Lewis H. Kuller [États-Unis] ; Kenneth M. Langa [États-Unis] ; Oscar L. Lopez [États-Unis] ; Katarina Kos [Royaume-Uni] ; Maya Soni [Royaume-Uni] ; David J. Llewellyn [Royaume-Uni]

Source :

Neurology [ 0028-3878 ] ; 2014.

RBID : Pascal:14-0238245

Descripteurs français

Pascal (Inist)
- Démence d'Alzheimer, Pathologie du système nerveux, Vitamine D, Facteur risque.

English descriptors

KwdEn :
- Alzheimer disease, Nervous system diseases, Risk factor, Vitamin D.

Abstract

Objective: To determine whether low vitamin D concentrations are associated with an increased risk of incident all-cause dementia and Alzheimer disease. Methods: One thousand six hundred fifty-eight elderly ambulatory adults free from dementia, cardiovascular disease, and stroke who participated in the US population-based Cardiovascular Health Study between 1992-1993 and 1999 were included. Serum 25-hydroxyvitamin D (25 (OH)D) concentrations were determined by liquid chromatography-tandem mass spectrometry from blood samples collected in 1992-1993. Incident all-cause dementia and Alzheimer disease status were assessed during follow-up using National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association criteria. Results: During a mean follow-up of 5.6 years, 171 participants developed all-cause dementia, including 102 cases of Alzheimer disease. Using Cox proportional hazards models, the multivariate adjusted hazard ratios (95% confidence interval [CI]) for incident all-cause dementia in participants who were severely 25(OH)D deficient (<25 nmol/L) and deficient (≥25 to <50 nmol/L) were 2.25 (95% CI: 1.23-4.13) and 1.53 (95% CI: 1.06-2.21) compared to participants with sufficient concentrations (≥50 nmol/L). The multivariate adjusted hazard ratios for incident Alzheimer disease in participants who were severely 25(OH)D deficient and deficient compared to participants with sufficient concentrations were 2.22 (95% CI: 1.02-4.83) and 1.69 (95% CI: 1.06-2.69). In multivariate adjusted penalized smoothing spline plots, the risk of all-cause dementia and Alzheimer disease markedly increased below a threshold of 50 nmol/L. Conclusion: Our results confirm that vitamin D deficiency is associated with a substantially increased risk of all-cause dementia and Alzheimer disease. This adds to the ongoing debate about the role of vitamin D in nonskeletal conditions.

Affiliations:

Links to Exploration step

Pascal:14-0238245

Le document en format XML

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<term>Risk factor</term>
<term>Vitamin D</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Démence d'Alzheimer</term>
<term>Pathologie du   système nerveux</term>
<term>Vitamine D</term>
<term>Facteur risque</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objective: To determine whether low vitamin D concentrations are associated with an increased risk of incident all-cause dementia and Alzheimer disease. Methods: One thousand six hundred fifty-eight elderly ambulatory adults free from dementia, cardiovascular disease, and stroke who participated in the US population-based Cardiovascular Health Study between 1992-1993 and 1999 were included. Serum 25-hydroxyvitamin D (25 (OH)D) concentrations were determined by liquid chromatography-tandem mass spectrometry from blood samples collected in 1992-1993. Incident all-cause dementia and Alzheimer disease status were assessed during follow-up using National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association criteria. Results: During a mean follow-up of 5.6 years, 171 participants developed all-cause dementia, including 102 cases of Alzheimer disease. Using Cox proportional hazards models, the multivariate adjusted hazard ratios (95% confidence interval [CI]) for incident all-cause dementia in participants who were severely 25(OH)D deficient (<25 nmol/L) and deficient (≥25 to <50 nmol/L) were 2.25 (95% CI: 1.23-4.13) and 1.53 (95% CI: 1.06-2.21) compared to participants with sufficient concentrations (≥50 nmol/L). The multivariate adjusted hazard ratios for incident Alzheimer disease in participants who were severely 25(OH)D deficient and deficient compared to participants with sufficient concentrations were 2.22 (95% CI: 1.02-4.83) and 1.69 (95% CI: 1.06-2.69). In multivariate adjusted penalized smoothing spline plots, the risk of all-cause dementia and Alzheimer disease markedly increased below a threshold of 50 nmol/L. Conclusion: Our results confirm that vitamin D deficiency is associated with a substantially increased risk of all-cause dementia and Alzheimer disease. This adds to the ongoing debate about the role of vitamin D in nonskeletal conditions.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Pays de la Loire</li>
<li>Pennsylvanie</li>
<li>Washington (État)</li>
<li>État de New York</li>
</region>
<settlement><li>Angers</li>
<li>New York</li>
<li>Pittsburgh</li>
<li>Seattle</li>
</settlement>
<orgName><li>Université Columbia</li>
<li>Université de Pittsburgh</li>
<li>Université de Washington</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><noRegion><name sortKey="Littlejohns, Thomas J" sort="Littlejohns, Thomas J" uniqKey="Littlejohns T" first="Thomas J." last="Littlejohns">Thomas J. Littlejohns</name>
</noRegion>
<name sortKey="Henley, William E" sort="Henley, William E" uniqKey="Henley W" first="William E." last="Henley">William E. Henley</name>
<name sortKey="Kos, Katarina" sort="Kos, Katarina" uniqKey="Kos K" first="Katarina" last="Kos">Katarina Kos</name>
<name sortKey="Lang, Iain A" sort="Lang, Iain A" uniqKey="Lang I" first="Iain A." last="Lang">Iain A. Lang</name>
<name sortKey="Llewellyn, David J" sort="Llewellyn, David J" uniqKey="Llewellyn D" first="David J." last="Llewellyn">David J. Llewellyn</name>
<name sortKey="Soni, Maya" sort="Soni, Maya" uniqKey="Soni M" first="Maya" last="Soni">Maya Soni</name>
</country>
<country name="France"><region name="Pays de la Loire"><name sortKey="Annweiler, Cedric" sort="Annweiler, Cedric" uniqKey="Annweiler C" first="Cedric" last="Annweiler">Cedric Annweiler</name>
</region>
<name sortKey="Beauchet, Olivier" sort="Beauchet, Olivier" uniqKey="Beauchet O" first="Olivier" last="Beauchet">Olivier Beauchet</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Chaves, Paulo H M" sort="Chaves, Paulo H M" uniqKey="Chaves P" first="Paulo H. M." last="Chaves">Paulo H. M. Chaves</name>
</noRegion>
<name sortKey="Fried, Linda" sort="Fried, Linda" uniqKey="Fried L" first="Linda" last="Fried">Linda Fried</name>
<name sortKey="Kestenbaum, Bryan R" sort="Kestenbaum, Bryan R" uniqKey="Kestenbaum B" first="Bryan R." last="Kestenbaum">Bryan R. Kestenbaum</name>
<name sortKey="Kuller, Lewis H" sort="Kuller, Lewis H" uniqKey="Kuller L" first="Lewis H." last="Kuller">Lewis H. Kuller</name>
<name sortKey="Langa, Kenneth M" sort="Langa, Kenneth M" uniqKey="Langa K" first="Kenneth M." last="Langa">Kenneth M. Langa</name>
<name sortKey="Langa, Kenneth M" sort="Langa, Kenneth M" uniqKey="Langa K" first="Kenneth M." last="Langa">Kenneth M. Langa</name>
<name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L." last="Lopez">Oscar L. Lopez</name>
</country>
</tree>
</affiliations>
</record>

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Vitamin D and the risk of dementia and Alzheimer disease

Vitamin D and the risk of dementia and Alzheimer disease

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